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Metformin Extended Release Treatment of Adolescent Obesity

A 48-Week Randomized, Double-Blind, Placebo-Controlled Trial With 48-Week Follow-up. Source: Glaser Pediatric Research Network Obesity Study Group as published in Archives of Pediatrics & Adolescent Medicine, Vol 164, No. 2, February 2010

In this small study (baseline n=77) obese (95th BMI percentile) adolescents (13-18 years of age) were enrolled in a lifestyle intervention program. Participants were randomized to receive a treatment (once daily 2000mg metformin hydrochloride) and to control. After 48 weeks a small change in BMI was noted in the treatment group. No effects of metformin on body composition, abdominal fat of insulin indeces were observed.

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