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Diabetes Prevention Interventions Have Long-Lasting Effects

The benefits of lifestyle intervention or metformin for preventing the development of diabetes in high-risk adults can persist for 10 years, according to a follow-up report from the Diabetes Prevention Program (DPP) trial published online in Lancet.

Researchers examined longer-term follow-up data on some 2800 high-risk adults who had been randomized to intensive lifestyle intervention, metformin, or placebo in the DPP trial. At the end of that period (roughly 3 years), both lifestyle intervention and metformin had significantly lowered diabetes incidence relative to placebo (by 58% and 31%, respectively). Then, all participants were offered lifestyle counseling; those originally assigned to lifestyle intervention received additional lifestyle support, while the metformin group continued their treatment.

Over a median of 10 years' total follow-up, benefits of the interventions persisted — overall diabetes incidence was reduced by 34% in the lifestyle group and by 18% in the metformin group, relative to placebo.

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